Lee滤波按定义实现：

from scipy.ndimage.filters import uniform_filter
from scipy.ndimage.measurements import variance

def lee_filter(img, size):
    img_mean = uniform_filter(img, (size, size))
    img_sqr_mean = uniform_filter(img**2, (size, size))
    img_variance = img_sqr_mean - img_mean**2

    overall_variance = variance(img)

    img_weights = img_variance / (img_variance + overall_variance)
    img_output = img_mean + img_weights * (img - img_mean)
    return img_output

Lee滤波调包，findpeaks提供lee, frost等多种滤波方法

pip install findpeaks

from findpeaks import findpeaks

# Read image
img = cv2.imread('noise.png')

filters = [None, 'lee','lee_enhanced','kuan', 'fastnl','bilateral','frost','median','mean']

for getfilter in filters:
    fp = findpeaks(method='topology', scale=False, denoise=getfilter, togray=True, imsize=False, window=15)
    fp.fit(img)
    fp.plot_mesh(wireframe=False, title=str(getfilter), view=(30,30))

更多使用findpeaks的去噪用法：

import findpeaks
import matplotlib.pyplot as plt

# Read image
img = cv2.imread('noise.png')

# filters parameters
# window size
winsize = 15
# damping factor for frost
k_value1 = 2.0
# damping factor for lee enhanced
k_value2 = 1.0
# coefficient of variation of noise
cu_value = 0.25
# coefficient of variation for lee enhanced of noise
cu_lee_enhanced = 0.523
# max coefficient of variation for lee enhanced
cmax_value = 1.73

# Some pre-processing
# Make grey image
img = findpeaks.stats.togray(img)
# Scale between [0-255]
img = findpeaks.stats.scale(img)

# Denoising
# fastnl
img_fastnl = findpeaks.stats.denoise(img, method='fastnl', window=winsize)
# bilateral
img_bilateral = findpeaks.stats.denoise(img, method='bilateral', window=winsize)
# frost filter
image_frost = findpeaks.frost_filter(img, damping_factor=k_value1, win_size=winsize)
# kuan filter
image_kuan = findpeaks.kuan_filter(img, win_size=winsize, cu=cu_value)
# lee filter
image_lee = findpeaks.lee_filter(img, win_size=winsize, cu=cu_value)
# lee enhanced filter
image_lee_enhanced = findpeaks.lee_enhanced_filter(img, win_size=winsize, k=k_value2, cu=cu_lee_enhanced, cmax=cmax_value)
# mean filter
image_mean = findpeaks.mean_filter(img, win_size=winsize)
# median filter
image_median = findpeaks.median_filter(img, win_size=winsize)


plt.figure(); plt.imshow(img_fastnl, cmap='gray'); plt.title('Fastnl')
plt.figure(); plt.imshow(img_bilateral, cmap='gray'); plt.title('Bilateral')
plt.figure(); plt.imshow(image_frost, cmap='gray'); plt.title('Frost')
plt.figure(); plt.imshow(image_kuan, cmap='gray'); plt.title('Kuan')
plt.figure(); plt.imshow(image_lee, cmap='gray'); plt.title('Lee')
plt.figure(); plt.imshow(image_lee_enhanced, cmap='gray'); plt.title('Lee Enhanced')
plt.figure(); plt.imshow(image_mean, cmap='gray'); plt.title('Mean')
plt.figure(); plt.imshow(image_median, cmap='gray'); plt.title('Median')

参考：Speckle ( Lee Filter) in Python - Stack Overflow