体外诊断丨艾美捷游离维多珠单抗ADA水平检测试剂盒

news2024/11/26 2:54:43

introduction:

Crohn's disease in patients with moderate to severe active ulcerative colitis, routine treatment or tumor necrosis factor α （TNF α） Antagonists can also be treated with vidolizumab. Vedolizumab is a humanized monoclonal therapeutic antibody, which selectively α four β Integrins bind to activated lymphocytes, preventing them from entering the intestinal mucosa. Vedolizumab attacks through TNF α The mechanism of action other than antagonists enters the inflammatory response and inhibits gastrointestinal inflammation.

The efficacy of vedolizumab treatment is usually dose related. The therapeutic antibody administered in the patient's serum can detect the patient, namely the so-called valley level. Various factors affect the height of valley level. These include: disease activity, individual differences in pharmacokinetics, and the emergence of anti drug antibodies (ADA).

Aimeijie Free Vitolimus McAb ADA Level Test Kit is used to determine free human antibody of Vitolimus McAb (such as ENTYVIO) ®) Applicable to EDTA plasma and serum. It is only used for in vitro diagnosis.

引言：

中度至重度活动型溃疡性结肠炎患者克罗恩病，常规治疗或肿瘤坏死因子α（TNFα）拮抗剂也可以用维多利单抗治疗。韦多利单抗是一种人源化单克隆治疗抗体，它选择性地将α4β7整合素与活化的淋巴细胞结合，从而阻止它们进入肠粘膜。韦多利单抗攻击通过TNFα拮抗剂以外的作用机制进入炎症反应并抑制胃肠道炎症。

维多利单抗治疗的疗效通常与剂量相关在患者血清中施用的治疗抗体可以检测到患者，即所谓的谷平面。各种因素影响着谷平面的高度。其中包括：疾病活动、药代动力学中的个体差异和抗药物抗体（ADA）的出现。

艾美捷游离维多珠单抗ADA水平检测试剂盒用于测定维多利单抗（如ENTYVIO）的游离人抗体®) 适用于EDTA血浆和血清。

只用于体外诊断。