Your Dog’s Behavior Is a Product of Their Genes
狗狗做什么，基因来决定

这篇好难，字基本都认识，但它不认识我~

“Identification of the genes behind dog behavior has historically been challenging,” says first author Emily Dutrow, postdoctoral fellow at the National Human Genome Research Institute.

“The inherent complexity of canine population dynamics features varying degrees of selective pressure for aesthetic and morphological traits, some of which may be linked to behavioral traits, so pinpointing the genetics of canine behavior can be complicated.”

Kennel clubs generally categorize dog breeds on the basis of the jobs they are best suited for.To find the genetic drivers of the behavioral tendencies that make dogs good at specific tasks, the researchers gathered whole-genome data from over 4,000 purebred, mixed-breed, and semi-feral dogs, as well as wild canids.

By applying computational tools originally developed for studying single cells rather than whole organisms, Dutrow and team identified 10 major genetic lineages among hundreds of dog breeds, solely on the basis of DNA data.

The researchers found that each lineage corresponded to a specific category of breeds historically used for tasks such as hunting by scent versus sight or herding versus protecting livestock, indicating that common sets of genes were responsible for behaviors among dog breeds well suited for similar tasks.

To understand the nature of these behaviors, the researchers turned to individual dog experts: pet owners.Using 46,000 behavioral assessment surveys sent to owners of purebred dogs, the researchers identified unique sets of behavioral tendencies among the 10 lineages of dogs.

“Having established significant behavioral tendencies correlated with the major canine lineages, we then identified genetic drivers of these behaviors by performing a genome-wide association study on the DNA samples,” says Dutrow.

“We were particularly interested in livestock-herding dogs, who display one of the most easily defined breed-typical behaviors, characterized by an instinctive herding drive coupled with unique motor patterns that move herds in complex ways.”

The researchers’ search led them to specific genes involved in brain wiring in herding dogs.They found that variants near genes involved in axon guidance, a process that shapes brain circuitry, appeared highly enriched.They also saw an enrichment for genes important for development of areas of the brain involved in social cognition and learned fear responses.

“When you get a certain input or stimulus, the degree to which that creates a reaction in different parts of the brain shapes how we behave,” says Ostrander.

“So, if nerves within and between brain regions don’t communicate in specific ways, then the behavior doesn’t happen, and this is where axon-guidance genes come into play.”