C1q是构成C1的一个重要成分，由小肠、结肠上皮细胞、血液中单核细胞、腹膜巨噬细胞、上皮细胞、肝脏、脾脏等合成。活化后能启发补体经典激活途径。

C1q蛋白家族由众多含C1q结构域的蛋白组成, 从细菌到高等哺乳动物中都有分布。这类蛋白由一条信号肽、胶原样区(Collage-like region, CLR)和C1q球状结构域(Globular C1q domain, gC1q)组成。C1q蛋白家族根据其结构特点, 可分为三大类分子：C1q、C1q-like和ghC1q。C1q是补体经典途径的起始分子, 能够识别免疫复合物, 启动补体系统经典途径; 此外, 作为一种模式识别受体分子(Pattern recognition receptor, PRR), 它可以结合种类繁多的配体。

艾美捷C1q天然蛋白的应用：

C1q的生物活性定义为产生50%致敏红细胞（EA）裂解所需的C1q量。对于功能性研究，体外稀释必须在用户的实验环境中进行优化。

 

 

艾美捷C1q天然蛋白化学性质:

Product type Proteins

Quantity 1 mg

Species Human

Formulation 1 ml of approximately 1 mg/ml purified natural human C1q isolated from healthy blood donors, in 10 mM HEPES, 300 mM NaCl, pH 7.2. The blood donors have been tested and found negative for various viruses (see table: Human blood test results). The functional activity is indicated on the label.

Use For functional studies, in vitro dilutions have to be optimized in user's experimental setting.

Application Functional studies

Storage and stability Product should be stored at -70 °C. Repeated freeze and thaw cycles will cause loss of activity. The exact expiry date is indicated on the label. Use C1q protein within 24 hours after thawing and keep on ice. Remainder amounts should be aliquoted and immediately re-freezed for future use. Aliquots should never be thawed more than once. Under recommended storage conditions, product is stable for at least one year.

Precautions For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.

Disease Nephrology, Neurological disorders

仅供研究使用。不用于人体或动物或诊断。

艾美捷C1q天然蛋白相关研究：

C5L2，人，多肽，10 ug  HC2103

重组人B-FABP，50 ug  HC2106

C1，人，正常，200 ug  HC2122*

C4，人，正常，250 ug  HC2128*

补体因子I，人，正常，100 ug  HC2131*

C1q，人类，天然，1毫克  HC2123