Usually the SAN is not exposed to the VM directly. Instead VMs use the file system exposed by the VM Manager.
In such cases we would suggest you to consider using VM settings.

When using SSD you can look at the following configuration variables :

a. innodb_page_size

You can reduce the page size to 4k or 8k , reducing it from the default of 16k.

b. innodb_flush_neighbors=0

c. innodb_lru_scan_depth=512

This is especially beneficial if you have a large buffer pool with more than 8 instances.

d. innodb_io_capacity

Since SSD based SAN is being used, you can try increasing this value from default.
We would suggest using IO bench-marking tools to determine the optimal IOPS value to be used.

Most enterprise class SSD can provide high IOPS values, please check with the vendor as well.


Another thing that helps in most situations is to disable ballooning driver when using VMWare VM.
 

https://kb.vmware.com/s/article/1002586