1.导入EPPlus.dll、Excel.dll、Mysql.Data.dll、System.Data.dll；（我这里用的是：Unity2017.3.0）

2.代码如下：

using System.Data;
using System.IO;
using UnityEngine;
using OfficeOpenXml;
using UnityEditor;
using Excel;

public class ExcelManager : MonoBehaviour
{
    #region 创建Excel表格
    [MenuItem("Excel操作/创建Excel表格")]
    static void 创建Excel表格()
    {
        string _filePath = Application.streamingAssetsPath + "/学生信息.xlsx";
        string _sheetName = "详情";

        FileInfo _excelName = new FileInfo(_filePath);
        if (_excelName.Exists)
        {
            //删除旧文件，并创建一个新的 excel 文件。
            _excelName.Delete();
            _excelName = new FileInfo(_filePath);
        }

        //通过ExcelPackage打开文件
        using (ExcelPackage package = new ExcelPackage(_excelName))
        {
            //在 excel 空文件添加新 sheet，并设置名称。
            ExcelWorksheet worksheet = package.Workbook.Worksheets.Add(_sheetName);

            //添加列名
            worksheet.Cells[1, 1].Value = "学号";
            worksheet.Cells[1, 2].Value = "姓名";
            worksheet.Cells[1, 3].Value = "性别";

            //添加一行数据
            worksheet.Cells[2, 1].Value = 100001;
            worksheet.Cells[2, 2].Value = "张三";
            worksheet.Cells[2, 3].Value = "男";

            //添加一行数据
            worksheet.Cells[3, 1].Value = 100002;
            worksheet.Cells[3, 2].Value = "李四";
            worksheet.Cells[3, 3].Value = "女";

            //添加一行数据
            worksheet.Cells[4, 1].Value = 120033;
            worksheet.Cells[4, 2].Value = "Saw";
            worksheet.Cells[4, 3].Value = "男";

            //保存excel
            package.Save();
        }
    }
    #endregion


    #region 读取Excel表格
    [MenuItem("Excel操作/读取Excel表格")]
    static void 读取Excel表格()
    {
        DataRowCollection _dataRowCollection = ReadExcel(Application.streamingAssetsPath + "/学生信息.xlsx");
        for (int i = 0; i < _dataRowCollection.Count; i++)
        {
            Debug.Log(_dataRowCollection[i][0] + " " + _dataRowCollection[i][1] + " " + _dataRowCollection[i][2]);
        }
    }

    //通过表的索引，返回一个DataRowCollection表数据对象
    static DataRowCollection ReadExcel(string _path, int _sheetIndex = 0)
    {
        FileStream stream = File.Open(_path, FileMode.Open, FileAccess.Read, FileShare.Read);
        IExcelDataReader excelReader = ExcelReaderFactory.CreateOpenXmlReader(stream);
        DataSet result = excelReader.AsDataSet();
        return result.Tables[_sheetIndex].Rows;
    }

    //通过表的名字，返回一个DataRowCollection表数据对象
    private DataRowCollection ReadExcel(string _path, string _sheetName)
    {
        FileStream stream = File.Open(_path, FileMode.Open, FileAccess.Read, FileShare.Read);
        IExcelDataReader excelReader = ExcelReaderFactory.CreateOpenXmlReader(stream);
        DataSet result = excelReader.AsDataSet();
        return result.Tables[_sheetName].Rows;
    }
    #endregion


    #region 改写Excel表格
    [MenuItem("Excel操作/改写Excel表格")]
    static void 改写Excel表格()
    {
        string path = Application.streamingAssetsPath + "/学生信息.xlsx";
        FileInfo _excelName = new FileInfo(path);
        using (ExcelPackage package = new ExcelPackage(_excelName))
        {
            ExcelWorksheet worksheet = package.Workbook.Worksheets["详情"];
            //修改某一行的数据
            worksheet.Cells[4, 3].Value = "人妖";
            //保存excel
            package.Save();
        }
    }
    #endregion
}

 dll资源文件夹：https://download.csdn.net/download/qq_41603955/90677810